Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 14/20 | 0.49 |
| ▸ | MMP13 | P45452 | 11/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 3/20 | 0.45 |
| ▸ | MMP2 | P08253 | 4/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7421426 | 0.94 | ADAM17 (0.47) | ADAM17MMP13ADAMTS4MMP1MMP2 | |
| SCHEMBL7430361 | 0.88 | ADAM17 (0.45) | ADAM17MMP13ADAMTS4MMP1MMP2 | |
| SCHEMBL7421651 | 0.86 | MMP1 (0.46) | ADAM17MMP13ADAMTS4MMP1MMP2 | |
| SCHEMBL7362510 | 0.85 | ADAM17 (0.58) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL7427244 | 0.84 | ADAM17 (0.42) | ADAM17MMP13ADAMTS4MMP1MMP2 | |
| SCHEMBL7427517 | 0.82 | ADAM17 (0.43) | ADAM17MMP13ADAMTS4MMP1MMP2 | |
| SCHEMBL7427644 | 0.80 | ADAM17 (0.42) | ADAM17MMP13ADAMTS4MMP1MMP2 | |
| SCHEMBL7354772 | 0.79 | ADAM17 (0.58) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL7353427 | 0.74 | ADAM17 (0.57) | ADAM17MMP13MMP1MMP2MMP9 | |
| SCHEMBL7950401 | 0.74 | MMP1 (0.50) | ADAM17MMP13ADAMTS4MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077974-A1 | SUBSTITUTED ARYL HYDROXAMIC ACIDS AS METALLOPROTEINASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2001-02-28 | — | — | EP | claimed |
| WO-1999058528-A1 | SUBSTITUTED ARYL HYDROXAMIC ACIDS AS METALLOPROTEINASE INHIBITORS | BRISTOL-MYERS SQUIBB PHARMA COMPANY. (US) | 1999-11-18 | — | — | WO | claimed |
| EP-1077974-A1 | SUBSTITUTED ARYL HYDROXAMIC ACIDS AS METALLOPROTEINASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999058528-A1 | SUBSTITUTED ARYL HYDROXAMIC ACIDS AS METALLOPROTEINASE INHIBITORS | BRISTOL-MYERS SQUIBB PHARMA COMPANY. (US) | 1999-11-18 | — | — | WO | disclosed |