Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 11/20 | 0.52 |
| ▸ | MMP1 | P03956 | 8/20 | 0.52 |
| ▸ | MMP2 | P08253 | 8/20 | 0.51 |
| ▸ | MMP9 | P14780 | 8/20 | 0.51 |
| ▸ | MMP7 | P09237 | 4/20 | 0.51 |
| ▸ | MMP14 | P50281 | 3/20 | 0.51 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylamine SCHEMBL8764733 | 0.98 | MMP3 (0.51) | MMP3MMP1MMP2MMP9MMP7 | |
| SCHEMBL7419821 | 0.97 | MMP3 (0.51) | MMP3MMP1MMP2MMP9MMP7 | |
| Formamide SCHEMBL8764728 | 0.96 | MMP3 (0.49) | MMP3MMP1MMP2MMP9MMP7 | |
| SCHEMBL8387059 | 0.94 | MMP1 (0.49) | MMP3MMP1MMP2MMP9MMP7 | |
| SCHEMBL6411992 | 0.93 | MMP1 (0.59) | MMP3MMP1MMP2MMP9MMP7 | |
| SCHEMBL7894400 | 0.90 | MMP1 (0.59) | MMP3MMP1MMP2MMP9MMP7 | |
| SCHEMBL8387026 | 0.90 | MMP1 (0.59) | MMP3MMP1MMP2MMP9MMP7 | |
| SCHEMBL6413515 | 0.90 | MMP1 (0.59) | MMP3MMP1MMP2MMP9MMP7 | |
| SCHEMBL7452724 | 0.89 | MMP1 (0.48) | MMP3MMP1MMP2MMP9MMP7 | |
| SCHEMBL6948615 | 0.89 | MMP1 (0.48) | MMP3MMP1MMP2MMP9MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784629-B1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEASES | DARWIN DISCOVERY LTD (GB) | 1999-04-28 | — | — | EP | claimed |
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | disclosed |
| EP-1047450-A1 | ACE INHIBITOR-MMP INHIBITOR COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | disclosed |
| WO-1999032150-A1 | ACE INHIBITOR-MMP INHIBITOR COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-07-01 | — | — | WO | disclosed |
| WO-1998025949-A1 | SUBSTITUTED 5-AMINO-1,3,4-THIADIAZOLE-2-THIONES | PROSCRIPT, INC. (US) | 1998-06-18 | — | — | WO | disclosed |