Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 11/20 | 0.69 |
| ▸ | MMP9 | P14780 | 11/20 | 0.69 |
| ▸ | MMP13 | P45452 | 10/20 | 0.69 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.69 |
| ▸ | MMP2 | P08253 | 8/20 | 0.66 |
| ▸ | MMP7 | P09237 | 6/20 | 0.66 |
| ▸ | MMP3 | P08254 | 5/20 | 0.66 |
| ▸ | PPARG | P37231 | 1/20 | 0.59 |
| ▸ | MMP14 | P50281 | 2/20 | 0.58 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.58 |
| ▸ | MMP8 | P22894 | 1/20 | 0.58 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.58 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8108645 | 0.91 | MMP1 (0.70) | MMP1MMP9MMP13ADAM17MMP2 | |
| SCHEMBL2511972 | 0.91 | MMP9 (0.68) | MMP1MMP9MMP13ADAM17MMP2 | |
| SCHEMBL2511969 | 0.91 | MMP9 (0.68) | MMP1MMP9MMP13ADAM17MMP2 | |
| SCHEMBL2514060 | 0.90 | MMP9 (0.67) | MMP1MMP9MMP13ADAM17MMP2 | |
| SCHEMBL2514059 | 0.90 | MMP9 (0.67) | MMP1MMP9MMP13ADAM17MMP2 | |
| SCHEMBL2516073 | 0.89 | MMP9 (0.65) | MMP1MMP9MMP13ADAM17MMP2 | |
| SCHEMBL2516070 | 0.89 | MMP9 (0.65) | MMP1MMP9MMP13ADAM17MMP2 | |
| SCHEMBL7417303 | 0.87 | MMP1 (0.68) | MMP1MMP9MMP13ADAM17MMP2 | |
| SCHEMBL2515895 | 0.86 | MMP9 (0.64) | MMP1MMP9MMP13ADAM17MMP2 | |
| SCHEMBL2515899 | 0.86 | MMP9 (0.64) | MMP1MMP9MMP13ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218389-B1 | FOR THERAPY AND PROPHYLAXIS OF ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS; SKIN DISORDERS; OCULAR DISORDERS; INFLAMMATION AND GUM DISEASES, MULTIPLE SCLEROSIS, CACHEXIA, PREVENTING LOOSENING OF PROSTHETIC DEVICES | THE PROCTER & GAMBLE CO. | 2001-04-17 | — | — | US | disclosed |
| EP-1009737-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999006340-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |