SCHEMBL7420443

SCHEMBL7420443

O=C(O)C1CN(C(=O)c2ccccc2)c2ccccc2CN1S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1

nearest known ligand 0.83

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 13/20 0.83
MMP13 P45452 13/20 0.83
ADAM17 P78536 13/20 0.83
MMP9 P14780 12/20 0.83
MMP8 P22894 7/20 0.60
MMP3 P08254 4/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7427908 0.91 MMP1 (0.81) MMP1MMP13ADAM17MMP9MMP8
SCHEMBL7421973 0.88 MMP1 (0.83) MMP1MMP13ADAM17MMP9MMP8
SCHEMBL6609170 0.87 MMP1 (0.82) MMP1MMP13ADAM17MMP9MMP3
SCHEMBL7569364 0.85 MMP1 (0.83) MMP1MMP13ADAM17MMP9MMP8
SCHEMBL6614910 0.82 MMP1 (0.84) MMP1MMP13ADAM17MMP9MMP3
SCHEMBL7421415 0.82 MMP1 (0.63) MMP1MMP13ADAM17MMP9MMP8
SCHEMBL6612567 0.81 MMP1 (0.73) MMP1MMP13ADAM17MMP9MMP3
SCHEMBL3940219 0.81 MMP13 (0.85) MMP1MMP13ADAM17MMP9
SCHEMBL6010114 0.81 MMP8 (0.84) MMP1MMP13ADAM17MMP9MMP8
SCHEMBL3950441 0.81 MMP13 (0.73) MMP1MMP13ADAM17MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051407-A1 2,3,4,5-TETRAHYDRO-1H-[1,4]-BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS American Cyanamid Company (US) 2000-11-15 EP claimed
US-6071903-A ENZYME INHIBITORS OF MATRIX METALLOPROTEINASES (MMPS); ANTITUMOR,-CARCINOGENIC AND -ARTHRITIC AGENTS; OSTEOARTHRITIS; RHEUMATOID DISEASES; DEGENERATIVE CARTILAGE LOSS; LONG-ACTING, ORALLY BIOAVAILABLE NONPEPTIDE INHIBITORS AMERICAN CYANAMID COMPANY (US) 2000-06-06 US claimed
WO-1999037625-A1 2,3,4,5-TETRAHYDRO-1H-[1,4]-BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1999-07-29 WO claimed
EP-1051407-A1 2,3,4,5-TETRAHYDRO-1H-[1,4]-BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS American Cyanamid Company (US) 2000-11-15 EP disclosed
US-6071903-A ENZYME INHIBITORS OF MATRIX METALLOPROTEINASES (MMPS); ANTITUMOR,-CARCINOGENIC AND -ARTHRITIC AGENTS; OSTEOARTHRITIS; RHEUMATOID DISEASES; DEGENERATIVE CARTILAGE LOSS; LONG-ACTING, ORALLY BIOAVAILABLE NONPEPTIDE INHIBITORS AMERICAN CYANAMID COMPANY (US) 2000-06-06 US disclosed
WO-1999037625-A1 2,3,4,5-TETRAHYDRO-1H-[1,4]-BENZODIAZEPINE-3-HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1999-07-29 WO disclosed