Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MB | P02144 | 2/20 | 0.45 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.31 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14703935 | 0.74 | CRBN (0.35) | — | |
| SCHEMBL28702765 | 0.70 | MB (0.33) | MB | |
| SCHEMBL15951381 | 0.69 | MB (0.66) | MB | |
| SCHEMBL7419264 | 0.69 | BIRC2 (0.37) | MBPARP16PARP3 | |
| SCHEMBL15595097 | 0.69 | MTOR (0.34) | — | |
| SCHEMBL13580189 | 0.67 | NNMT (0.34) | — | |
| SCHEMBL7414875 | 0.62 | CYP11B1 (0.46) | MB | |
| SCHEMBL15074619 | 0.62 | MB (0.66) | MB | |
| SCHEMBL6074407 | 0.62 | MB (0.49) | MB | |
| SCHEMBL15951375 | 0.62 | MB (1.00) | MB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5002944-A | Compounds having cardiotonic activity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-03-26 | — | — | US | disclosed |
| EP-0333727-A1 | HETEROCYCLIC SUBSTITUTED BICYCLOUREAS HAVING CARDIOTONIC ACTIVITY | RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation) (US) | 1989-09-27 | — | — | EP | disclosed |
| US-4859672-A | Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone | RORER PHARMACEUTICAL CORPORATION (US) | 1989-08-22 | — | — | US | disclosed |
| WO-1988003025-A1 | HETEROCYCLIC SUBSTITUTED BICYCLOUREAS HAVING CARDIOTONIC ACTIVITY | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1988-05-05 | — | — | WO | disclosed |