Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.38 |
| ▸ | DPP4 | P27487 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 3/20 | 0.36 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423692 | 0.88 | ALOX5AP (0.41) | ALOX5APPLA2G2ADPP4CYP1A2CYP3A4 | |
| SCHEMBL7421847 | 0.87 | ALOX5AP (0.43) | ALOX5APPLA2G2ADPP4CYP1A2CYP3A4 | |
| SCHEMBL29611861 | 0.86 | ALOX5AP (0.47) | ALOX5APPLA2G2ADPP4CYP1A2CYP3A4 | |
| SCHEMBL687131 | 0.86 | ALOX5AP (0.47) | ALOX5APPLA2G2ADPP4CYP1A2CYP3A4 | |
| SCHEMBL7424518 | 0.86 | ALOX5AP (0.43) | ALOX5APPLA2G2ADPP4CYP1A2CYP3A4 | |
| SCHEMBL7426692 | 0.86 | ALOX5AP (0.43) | ALOX5APPLA2G2ADPP4CYP1A2CYP3A4 | |
| SCHEMBL7420199 | 0.86 | SLC22A12 (0.37) | PLA2G2ACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL7471716 | 0.85 | ALOX5AP (0.41) | ALOX5APPLA2G2ADPP4CYP1A2CYP3A4 | |
| SCHEMBL7424858 | 0.84 | L3MBTL1 (0.47) | ALOX5APPLA2G2ADPP4CYP1A2CYP3A4 | |
| SCHEMBL7421169 | 0.84 | PLA2G2A (0.43) | ALOX5APPLA2G2ADPP4TP53CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |