Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960446 | 0.89 | RAB9A (0.57) | SMN1; SMN2RAB9AMAPK1LMNAKMT2A | |
| SCHEMBL7949930 | 0.86 | MAPT (0.54) | SMN1; SMN2RAB9AMAPK1LMNAKMT2A | |
| SCHEMBL7415683 | 0.86 | RAB9A (0.42) | SMN1; SMN2RAB9AMAPK1KMT2AMEN1 | |
| SCHEMBL7418952 | 0.86 | RAB9A (0.44) | SMN1; SMN2RAB9ALMNAKMT2AGAA | |
| SCHEMBL7418016 | 0.85 | KMT2A (0.51) | SMN1; SMN2RAB9ALMNAKMT2AMEN1 | |
| SCHEMBL7958034 | 0.85 | MEN1 (0.44) | SMN1; SMN2RAB9ALMNAKMT2AMEN1 | |
| SCHEMBL6219646 | 0.84 | LMNA (0.44) | SMN1; SMN2RAB9ARXFP1LMNAGAA | |
| SCHEMBL6220101 | 0.84 | LMNA (0.43) | SMN1; SMN2RAB9ARXFP1LMNAMITF | |
| SCHEMBL6221743 | 0.84 | LMNA (0.44) | SMN1; SMN2RAB9ARXFP1LMNAGAA | |
| Hydrochloric Acid SCHEMBL6225831 | 0.84 | LMNA (0.43) | SMN1; SMN2RAB9ARXFP1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639760-A | USEFUL AS MUSCLE RELAXANTS, SEDATIVES, ANXIOLYTICS, ANTICONVULSANTS, AND ANTIDOTES FOR DRUG OVERDOSE | MARYANOFF BRUCE E (US) | 1997-06-17 | — | — | US | claimed |
| US-6218384-B1 | FOR THERAPY OF ANXIETY, MUSCLE SPASMS, SLEEPLESSNESS, CONVULSIONS AND BENZODIAZEPINE OVERDOSES | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2001-04-17 | — | — | US | disclosed |
| US-5639760-A | USEFUL AS MUSCLE RELAXANTS, SEDATIVES, ANXIOLYTICS, ANTICONVULSANTS, AND ANTIDOTES FOR DRUG OVERDOSE | MARYANOFF BRUCE E (US) | 1997-06-17 | — | — | US | disclosed |
| WO-1994004532-A1 | 3-OXO-PYRIDO(1,2-A^_)BENZIMIDAZOLE-4-CARBOXYL AND 4-OXO-AZEPINO(1,2-A^_)BENZIMIDAZOLE-5-CARBOXYL DERIVATIVES USEFUL IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS | MCNEILAB, INC. (US) | 1994-03-03 | — | — | WO | disclosed |