Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 14/20 | 0.49 |
| ▸ | TPSD1 | Q9BZJ3 | 14/20 | 0.49 |
| ▸ | TPSG1 | Q9NRR2 | 14/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.49 |
| ▸ | F2 | P00734 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 3/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420536 | 0.80 | TPSAB1 (0.74) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7417450 | 0.79 | ALDH1A1 (0.55) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL18753774 | 0.71 | ALDH1A1 (0.46) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL17696095 | 0.69 | CA12 (0.48) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL19423907 | 0.69 | ALDH1A1 (0.69) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL13144178 | 0.69 | ALDH1A1 (0.64) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL18753805 | 0.68 | TPSAB1 (0.45) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL15228686 | 0.67 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL13144177 | 0.67 | HPGD (0.62) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL10495198 | 0.67 | ALDH1A1 (0.89) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0782571-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1997-07-09 | — | — | EP | claimed |
| WO-1996009297-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1996-03-28 | — | — | WO | claimed |
| US-6022969-A | Compositions and methods for treating mast-cell mediated conditions | AXYS PHARMACEUTICALS, INC. (US) | 2000-02-08 | — | — | US | disclosed |