Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 18/20 | 0.74 |
| ▸ | TPSD1 | Q9BZJ3 | 18/20 | 0.74 |
| ▸ | TPSG1 | Q9NRR2 | 18/20 | 0.74 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.61 |
| ▸ | F2 | P00734 | 6/20 | 0.61 |
| ▸ | PLG | P00747 | 3/20 | 0.61 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.55 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415237 | 0.85 | TPSAB1 (1.00) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7422609 | 0.82 | TPSAB1 (0.83) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7420672 | 0.80 | TPSAB1 (0.49) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL23840665 | 0.79 | HPGD (0.63) | HRH3 | |
| SCHEMBL23840713 | 0.78 | HPGD (0.67) | HRH3 | |
| SCHEMBL23840708 | 0.77 | HRH3 (0.54) | HRH3 | |
| SCHEMBL7428430 | 0.76 | TPSAB1 (1.00) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL2379445 | 0.76 | HRH3 (0.61) | HRH3 | |
| SCHEMBL17696095 | 0.74 | CA12 (0.48) | TPSAB1TPSD1TPSG1PRSS1F2 | |
| SCHEMBL7418203 | 0.74 | TPSAB1 (1.00) | TPSAB1TPSD1TPSG1PRSS1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211228-B1 | COMPOUNDS WITH AMINO, GUANIDINO AND AMIDINO HETEROCYCLIC COMPOUNDS | AXYS PHARMACEUTICALS, INC | 2001-04-03 | — | — | US | disclosed |
| US-6022969-A | Compositions and methods for treating mast-cell mediated conditions | AXYS PHARMACEUTICALS, INC. (US) | 2000-02-08 | — | — | US | disclosed |
| EP-0782571-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009297-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL INFLAMMATORY CONDITION | ARRIS PHARMACEUTICAL CORPORATION (US) | 1996-03-28 | — | — | WO | disclosed |