SCHEMBL7420919

SCHEMBL7420919

CC(C)CC[C@H](NC(=O)OC(C)(C)C)C(=O)NO

nearest known ligand 0.54

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CTSK P43235 8/20 0.54
CTSS P25774 7/20 0.54
CTSL P07711 2/20 0.54
CTSB P07858 1/20 0.54
CA1 P00915 1/20 0.49
CA2 P00918 1/20 0.49
CA7 P43166 1/20 0.49
CAPN1 P07384 1/20 0.47
MMP13 P45452 2/20 0.45
AAK1 Q2M2I8 1/20 0.45
HDAC4 P56524 2/20 0.43
HDAC1 Q13547 2/20 0.43
HDAC6 Q9UBN7 1/20 0.42
CYP2D6 P10635 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL245261 0.87 CTSK (0.68) CTSKCTSSCTSLCTSBCA1
SCHEMBL8140278 0.85 CTSK (0.67) CTSKCTSSCTSLCTSBCA1
SCHEMBL18966404 0.84 CTSS (0.55) CTSKCTSSCTSLCTSBCA2
SCHEMBL23782062 0.83 CTSK (0.52) CTSKCTSSCTSLCTSBCA1
SCHEMBL4804217 0.83 CTSK (0.52) CTSKCTSSCTSLCTSBCA1
SCHEMBL6508453 0.83 CTSK (0.52) CTSKCTSSCTSLCTSBCA1
SCHEMBL8138631 0.83 CTSK (0.68) CTSKCTSSCA1CA2HDAC4
SCHEMBL245191 0.83 CTSK (0.68) CTSKCTSSCA1CA2HDAC4
SCHEMBL8278679 0.82 CTSL (0.49) CTSKCTSSCTSLCTSBCA1
SCHEMBL23782065 0.82 CTSL (0.49) CTSKCTSSCTSLCTSBCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6018020-A VIRICIDES WHICH ARE PROTEASE INHIBITORS AGAINST HEPATITIS C AND HEPATITIS G HOFFMAN-LA ROCHE INC. (US) 2000-01-25 US disclosed
EP-0941233-A2 ANTIVIRAL PEPTIDE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1999-09-15 EP disclosed
US-5866684-A Peptidyl inhibitors of viral proteases HOFFMANN-LA ROCHE INC. (US) 1999-02-02 US disclosed
WO-1998022496-A2 ANTIVIRAL PEPTIDE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1998-05-28 WO disclosed