Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | AGER | Q15109 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13858736 | 0.82 | SIGMAR1 (0.59) | SIGMAR1MEN1KMT2AMAPTTAAR1 | |
| SCHEMBL2548456 | 0.79 | PYCR1 (0.48) | PYCR1CTSKSIGMAR1NPC1RAB9A | |
| SCHEMBL11693602 | 0.74 | SIGMAR1 (0.46) | PYCR1CTSKSIGMAR1NPC1RAB9A | |
| SCHEMBL3833687 | 0.73 | SIGMAR1 (0.79) | SIGMAR1CYP1A2CYP2D6LMNATAAR1 | |
| SCHEMBL5854794 | 0.73 | IDO1 (0.38) | PYCR1CTSKNPC1RAB9ACYP1A2 | |
| SCHEMBL17605856 | 0.70 | PYCR1 (0.44) | PYCR1CTSKSIGMAR1NPC1RAB9A | |
| SCHEMBL13041050 | 0.70 | SMN1; SMN2 (0.70) | CYP1A2CYP2D6CYP2C19MEN1KMT2A | |
| SCHEMBL21966166 | 0.70 | PYCR1 (0.41) | PYCR1CTSKSIGMAR1NPC1RAB9A | |
| SCHEMBL9288254 | 0.70 | AGER (0.61) | NPC1RAB9AMEN1KMT2AL3MBTL1 | |
| SCHEMBL17605180 | 0.70 | PYCR1 (0.44) | PYCR1CTSKSIGMAR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934265-A1 | AMIDINOPHENYL-PYRROLIDINES, -PYRROLINES, AND -ISOXAZOLIDINES AND DERIVATIVES THEREOF | Du Pont Pharmaceuticals Company (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998006694-A1 | AMIDINOPHENYL-PYRROLIDINES, -PYRROLINES, AND -ISOXAZOLIDINES AND DERIVATIVES THEREOF | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-02-19 | — | — | WO | disclosed |