Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.59 |
| ▸ | DRD2 | P14416 | 7/20 | 0.52 |
| ▸ | DRD4 | P21917 | 7/20 | 0.52 |
| ▸ | DRD3 | P35462 | 7/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29525493 | 0.81 | POLB (0.65) | POLBDRD2DRD4DRD3CHRM2 | |
| SCHEMBL8556193 | 0.81 | POLB (0.65) | POLBDRD2DRD4DRD3CHRM2 | |
| SCHEMBL19852526 | 0.80 | POLB (0.55) | POLBDRD2DRD4DRD3CHRM2 | |
| SCHEMBL17969134 | 0.79 | POLB (0.67) | POLBDRD2DRD4DRD3CHRM2 | |
| SCHEMBL5641249 | 0.78 | MAPT (0.58) | POLBDRD2DRD4DRD3MAPK8 | |
| SCHEMBL17979351 | 0.78 | DRD2 (0.69) | POLBDRD2DRD4DRD3CHRM2 | |
| SCHEMBL30483504 | 0.78 | DRD2 (0.69) | POLBDRD2DRD4DRD3CHRM2 | |
| SCHEMBL6656950 | 0.77 | POLB (0.65) | POLBDRD2DRD4DRD3CHRM2 | |
| SCHEMBL30460612 | 0.77 | POLB (0.65) | POLBDRD2DRD4DRD3CHRM2 | |
| SCHEMBL30100689 | 0.76 | POLB (0.71) | POLBDRD2DRD4DRD3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0641323-A1 | CARBOSTYRIL DERIVATIVES AS MATRIX METALLOPROTEINASES INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-03-08 | — | — | EP | claimed |
| WO-1994021612-A1 | CARBOSTYRIL DERIVATIVES AS MATRIX METALLOPROTEINASES INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-29 | — | — | WO | claimed |