Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 4/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ABAT | P80404 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28093052 | 0.85 | CES1 (0.38) | F2PRSS1LMNAPOLB | |
| SCHEMBL28508417 | 0.78 | LOXL2 (0.62) | LOXL2 | |
| SCHEMBL8370038 | 0.78 | TSHR (0.48) | HDAC6ALDH1A1 | |
| SCHEMBL23201209 | 0.77 | LOXL2 (0.43) | LOXL2HDAC3HDAC6NCOR2F2 | |
| Trifluoroacetic Acid SCHEMBL28281967 | 0.77 | LOXL2 (0.77) | LOXL2HDAC3HDAC6NCOR2MEN1 | |
| SCHEMBL2455339 | 0.77 | NPC1 (0.49) | ALDH1A1 | |
| SCHEMBL5781148 | 0.77 | LOXL2 (0.61) | LOXL2HDAC3HDAC6NCOR2F2 | |
| SCHEMBL2081869 | 0.76 | MAPT (0.38) | LOXL2KMT2APOLBMAOB | |
| SCHEMBL22657796 | 0.76 | PRSS1 (0.54) | LOXL2F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7052967 | 0.76 | CES1 (0.54) | LOXL2HDAC3HDAC6NCOR2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073624-A1 | AMINOMETHYL-BENZOIC ESTER DERIVATIVES AS TRYPTASE INHIBITORS | Proteus Molecular Design Limited (GB) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999055661-A1 | AMINOMETHYL-BENZOIC ESTER DERIVATIVES AS TRYPTASE INHIBITORS | PROTEUS MOLECULAR DESIGN LIMITED (GB) | 1999-11-04 | — | — | WO | disclosed |