Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.36 |
| ▸ | PLG | P00747 | 2/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MASP2 | O00187 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.33 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL30387154 | 0.83 | LOXL2 (0.50) | LOXL2HDAC3HDAC6NCOR2F10 | |
| SCHEMBL25054199 | 0.81 | MASP2 (0.44) | LOXL2HDAC3HDAC6NCOR2F10 | |
| Trifluoroacetic Acid SCHEMBL30386986 | 0.79 | MASP2 (0.44) | LOXL2HDAC3HDAC6NCOR2F10 | |
| Trifluoroacetic Acid SCHEMBL30385710 | 0.79 | LOXL2 (0.42) | LOXL2HDAC3HDAC6NCOR2F10 | |
| Hydrochloric Acid SCHEMBL5846568 | 0.79 | LOXL2 (0.47) | LOXL2HDAC3HDAC6NCOR2F10 | |
| Trifluoroacetic Acid SCHEMBL23201208 | 0.78 | HDAC3 (0.44) | LOXL2HDAC3HDAC6NCOR2F10 | |
| SCHEMBL31205801 | 0.78 | LOXL2 (0.39) | LOXL2HDAC3HDAC6NCOR2F10 | |
| SCHEMBL7422144 | 0.77 | LOXL2 (0.56) | LOXL2HDAC3HDAC6NCOR2F10 | |
| SCHEMBL5731734 | 0.77 | LOXL2 (0.49) | LOXL2HDAC3HDAC6NCOR2F10 | |
| Trifluoroacetic Acid SCHEMBL30386559 | 0.77 | MASP2 (0.42) | LOXL2HDAC3HDAC6NCOR2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230145071-A1 | MASP-2 INHIBITORS AND METHODS OF USE | OMEROS CORPORATION | 2023-05-11 | — | — | US | disclosed |
| US-11584714-B2 | MASP-2 inhibitors and methods of use | OMEROS CORPORATION (US) | 2023-02-21 | — | — | US | disclosed |
| EP-3802489-A2 | MASP-2 INHIBITORS AND METHODS OF USE | Omeros Corporation (US) | 2021-04-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584714-B2 | MASP-2 inhibitors and methods of use | MASP2, METAP2, SPINT2 | LOXL2 1380/4885HDAC3 2682/4885HDAC6 1158/4885 |
| US-20230145071-A1 | MASP-2 INHIBITORS AND METHODS OF USE | MASP2, METAP2, SPINT2 | LOXL2 1380/4885HDAC3 2682/4885HDAC6 1158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.