Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 18/20 | 0.54 |
| ▸ | MMP9 | P14780 | 10/20 | 0.54 |
| ▸ | MMP13 | P45452 | 10/20 | 0.54 |
| ▸ | MMP14 | P50281 | 9/20 | 0.54 |
| ▸ | MMP8 | P22894 | 8/20 | 0.54 |
| ▸ | MMP2 | P08253 | 8/20 | 0.54 |
| ▸ | MMP1 | P03956 | 4/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | MMP10 | P09238 | 10/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430094 | 0.92 | MMP3 (0.54) | MMP3MMP9MMP13MMP14MMP8 | |
| SCHEMBL7436568 | 0.79 | MMP3 (0.63) | MMP3MMP9MMP13MMP14MMP8 | |
| SCHEMBL7397587 | 0.77 | MMP3 (0.67) | MMP3MMP9MMP13MMP14MMP8 | |
| Hydrochloric Acid SCHEMBL6689267 | 0.76 | MMP3 (0.66) | MMP3MMP9MMP13MMP14MMP8 | |
| SCHEMBL6684290 | 0.75 | MMP14 (0.62) | MMP3MMP9MMP13MMP14MMP8 | |
| Hydrochloric Acid SCHEMBL7174677 | 0.73 | MMP13 (0.56) | MMP3MMP9MMP13MMP14MMP8 | |
| Hydrochloric Acid SCHEMBL6897571 | 0.73 | MMP13 (0.56) | MMP3MMP9MMP13MMP14MMP8 | |
| Hydrochloric Acid SCHEMBL6691936 | 0.72 | MMP3 (0.63) | MMP3MMP9MMP13MMP14MMP8 | |
| Hydrochloric Acid SCHEMBL6691931 | 0.72 | MMP3 (0.60) | MMP3MMP9MMP13MMP14MMP8 | |
| SCHEMBL5919515 | 0.71 | MMP3 (1.00) | MMP3MMP9MMP13MMP14MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183239-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069821-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-11-23 | — | — | WO | disclosed |