Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NR1D1 | P20393 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8700638 | 0.81 | HTT (0.52) | HTTMAPTTSHRCYP1A2CYP2C19 | |
| SCHEMBL8406870 | 0.73 | CYP2C19 (0.48) | HTTMAPTTSHRCYP1A2CYP2C19 | |
| SCHEMBL8407013 | 0.73 | CYP2C19 (0.48) | HTTMAPTTSHRCYP1A2CYP2C19 | |
| SCHEMBL24650855 | 0.72 | MAPT (0.41) | HTTMAPTTSHRCYP1A2CYP2C19 | |
| SCHEMBL7423975 | 0.70 | MAPT (0.36) | MAPTTSHRALDH1A1NPC1RAB9A | |
| SCHEMBL13159207 | 0.66 | CYP2C19 (0.46) | HTTTSHRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL9770005 | 0.66 | MAPT (0.38) | HTTMAPTTSHRCYP1A2CYP2C19 | |
| SCHEMBL8049334 | 0.66 | TSHR (0.45) | MAPTTSHRCYP1A2CYP2C19ATM | |
| SCHEMBL8037835 | 0.66 | TSHR (0.45) | MAPTTSHRCYP1A2CYP2C19ATM | |
| SCHEMBL1477389 | 0.65 | TSHR (0.50) | MAPTTSHRCYP1A2CYP2C19MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5789415-A | Azacyclic-heterocyclic compounds as angiotension II receptor antagonists | PFIZER INC. (US) | 1998-08-04 | — | — | US | disclosed |
| WO-1995002596-A1 | AZACYCLIC-HETEROCYCLIC COMPOUNDS AS ANGIOTENSIN II RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1995-01-26 | — | — | WO | disclosed |