Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422279 | 0.81 | HTT (0.39) | HTTMAPTALDH1A1KMT2ATSHR | |
| SCHEMBL8407013 | 0.77 | CYP2C19 (0.48) | HTTMAPTALDH1A1KMT2AKDM4E | |
| SCHEMBL8406870 | 0.77 | CYP2C19 (0.48) | HTTMAPTALDH1A1KMT2AKDM4E | |
| SCHEMBL24650855 | 0.76 | MAPT (0.41) | HTTMAPTALDH1A1KMT2AKDM4E | |
| SCHEMBL7214018 | 0.72 | MEN1 (0.50) | KMT2ABRD4POLBMEN1NPSR1 | |
| SCHEMBL9097432 | 0.71 | HTT (0.43) | HTTMAPTALDH1A1PKMADORA2B | |
| SCHEMBL9095969 | 0.71 | HTT (0.42) | HTTMAPTALDH1A1PKMADORA2B | |
| SCHEMBL8700636 | 0.71 | PKM (0.42) | HTTMAPTALDH1A1PKMADORA2B | |
| SCHEMBL13159207 | 0.69 | CYP2C19 (0.46) | HTTALDH1A1KMT2AKDM4ETSHR | |
| SCHEMBL9770005 | 0.69 | MAPT (0.38) | HTTMAPTPKMKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5789415-A | Azacyclic-heterocyclic compounds as angiotension II receptor antagonists | PFIZER INC. (US) | 1998-08-04 | — | — | US | disclosed |