Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 19/20 | 0.73 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.73 |
| ▸ | PDE4A | P27815 | 13/20 | 0.73 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7419170 | 1.00 | PDE4D (0.73) | PDE4DPDE4BPDE4APDE4CABCB11 | |
| SCHEMBL7422159 | 0.92 | PDE4D (0.73) | PDE4DPDE4BPDE4APDE4CABCB11 | |
| SCHEMBL7421279 | 0.85 | PDE4D (0.78) | PDE4DPDE4BPDE4APDE4CABCB11 | |
| SCHEMBL29824395 | 0.84 | PDE4D (0.77) | PDE4DPDE4BPDE4APDE4CABCB11 | |
| SCHEMBL2888064 | 0.84 | PDE4D (0.77) | PDE4DPDE4BPDE4APDE4CABCB11 | |
| Piclamilast SCHEMBL26573 | 0.84 | PDE4D (1.00) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL15085259 | 0.84 | PDE4D (0.77) | PDE4DPDE4BPDE4APDE4CABCB11 | |
| SCHEMBL7379219 | 0.84 | PDE4D (0.79) | PDE4DPDE4BPDE4APDE4CABCB11 | |
| SCHEMBL7335911 | 0.83 | PDE4D (0.98) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7421422 | 0.83 | PDE4D (0.79) | PDE4DPDE4BPDE4APDE4CABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995004046-A1 | COMPOUNDS AS PDE IV AND TNF INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-02-09 | — | — | WO | disclosed |