Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 10/20 | 0.46 |
| ▸ | RAB9A | P51151 | 8/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28750791 | 0.93 | NPC1 (0.45) | FFAR1NPC1RAB9ALMNAFFAR4 | |
| SCHEMBL27578899 | 0.92 | NPC1 (0.44) | FFAR1NPC1RAB9ALMNAFFAR4 | |
| SCHEMBL7427523 | 0.90 | NPC1 (0.49) | FFAR1NPC1RAB9ALMNAFFAR4 | |
| SCHEMBL27570763 | 0.88 | FFAR1 (0.44) | FFAR1NPC1RAB9AFFAR4 | |
| SCHEMBL27578904 | 0.87 | NPC1 (0.43) | FFAR1NPC1RAB9AMRGPRX4 | |
| SCHEMBL7432425 | 0.86 | MEN1 (0.47) | NPC1RAB9A | |
| SCHEMBL27570769 | 0.85 | APP (0.43) | FFAR1NPC1RAB9AALDH1A1POLB | |
| SCHEMBL27570759 | 0.85 | GRM5 (0.43) | FFAR1NPC1RAB9AFFAR4ALDH1A1 | |
| SCHEMBL7429230 | 0.85 | RAB9A (0.45) | NPC1RAB9ALMNAMRGPRX4 | |
| SCHEMBL27570770 | 0.84 | S1PR1 (0.47) | FFAR1NPC1RAB9AFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1413210-A | Non-peptidyl inhibitors of VLA-4 dependent cell binding for the treatment of inflammation, autoimmune diseases and respiratory diseases | PFIZER PROD INC (US) | 2003-04-23 | — | — | CN | disclosed |
| EP-1244656-A1 | NON-PEPTIDYL INHIBITORS OF VLA-4 DEPENDENT CELL BINDING USEFUL IN TREATING INFLAMMATORY, AUTOIMMUNE, AND RESPIRATORY DISEASES | Pfizer Products Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001051487-A1 | NON-PEPTIDYL INHIBITORS OF VLA-4 DEPENDENT CELL BINDING USEFUL IN TREATING INFLAMMATORY, AUTOIMMUNE, AND RESPIRATORY DISEASES | PFIZER PRODUCTS INC. (US) | 2001-07-19 | — | — | WO | disclosed |