Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | APP | P05067 | 9/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27570769 | 0.95 | APP (0.43) | MEN1KMT2ANPC1RAB9AAPP | |
| SCHEMBL7429230 | 0.94 | RAB9A (0.45) | MEN1KMT2ANPC1RAB9AAPP | |
| SCHEMBL7583778 | 0.94 | FFAR1 (0.44) | MEN1KMT2ANPC1RAB9AAPP | |
| SCHEMBL27570759 | 0.93 | GRM5 (0.43) | MEN1KMT2ANPC1RAB9AAPP | |
| SCHEMBL27570763 | 0.93 | FFAR1 (0.44) | MEN1KMT2ANPC1RAB9AAPP | |
| SCHEMBL7429711 | 0.91 | FFAR4 (0.42) | MEN1KMT2AITGB1ITGA4 | |
| SCHEMBL27570770 | 0.91 | S1PR1 (0.47) | NPC1RAB9AITGB1ITGA4 | |
| SCHEMBL7431219 | 0.90 | RAB9A (0.42) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7439258 | 0.89 | S1PR1 (0.41) | NPC1RAB9AAPP | |
| SCHEMBL7484133 | 0.87 | FFAR4 (0.43) | NPC1RAB9AITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244656-A1 | NON-PEPTIDYL INHIBITORS OF VLA-4 DEPENDENT CELL BINDING USEFUL IN TREATING INFLAMMATORY, AUTOIMMUNE, AND RESPIRATORY DISEASES | Pfizer Products Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001051487-A1 | NON-PEPTIDYL INHIBITORS OF VLA-4 DEPENDENT CELL BINDING USEFUL IN TREATING INFLAMMATORY, AUTOIMMUNE, AND RESPIRATORY DISEASES | PFIZER PRODUCTS INC. (US) | 2001-07-19 | — | — | WO | disclosed |