Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424622 | 0.90 | AGTR1 (0.51) | AGTR1AGTR2KDM4E | |
| SCHEMBL7422487 | 0.89 | AGTR1 (0.45) | HTTAGTR1AGTR2KMT2AMEN1 | |
| SCHEMBL7422342 | 0.86 | S1PR3 (0.42) | HTTS1PR3KMT2AMEN1KDM4E | |
| SCHEMBL7420331 | 0.85 | S1PR3 (0.41) | S1PR3KMT2AMEN1KDM4E | |
| SCHEMBL7425401 | 0.85 | MAPT (0.43) | S1PR3KMT2AMEN1KDM4E | |
| SCHEMBL7470080 | 0.85 | S1PR3 (0.41) | AGTR1AGTR2S1PR3KDM4E | |
| SCHEMBL7468201 | 0.85 | MEN1 (0.43) | AGTR1AGTR2S1PR3KMT2AMEN1 | |
| SCHEMBL7416292 | 0.85 | S1PR3 (0.46) | S1PR3KMT2AMEN1 | |
| SCHEMBL7424404 | 0.85 | S1PR3 (0.42) | S1PR3KDM4E | |
| SCHEMBL7467554 | 0.83 | TSHR (0.43) | HTTS1PR3KMT2AMEN1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |