Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 7/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424763 | 0.90 | AGTR1 (0.39) | S1PR3KDM4EALDH1A1 | |
| SCHEMBL7422342 | 0.89 | S1PR3 (0.42) | S1PR3PTGER4KDM4EALDH1A1TDP1 | |
| SCHEMBL7422986 | 0.89 | PLA2G2A (0.40) | ACSS2KDM4EALDH1A1F10MAPT | |
| SCHEMBL7420331 | 0.88 | S1PR3 (0.41) | S1PR3PTGER4ACSS2KDM4ETP53 | |
| SCHEMBL7425401 | 0.88 | MAPT (0.43) | S1PR3KDM4EALDH1A1TDP1TP53 | |
| SCHEMBL7416292 | 0.88 | S1PR3 (0.46) | S1PR3ALDH1A1TP53MAPT | |
| SCHEMBL7468201 | 0.88 | MEN1 (0.43) | S1PR3MAPK8TP53MAPTTHRB | |
| SCHEMBL7470080 | 0.88 | S1PR3 (0.41) | S1PR3PTGER4KDM4ETP53MAPT | |
| SCHEMBL7423356 | 0.86 | S1PR3 (0.47) | S1PR3TP53MAPTTHRB | |
| SCHEMBL7467554 | 0.85 | TSHR (0.43) | S1PR3ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |