Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.51 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.51 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422487 | 0.92 | AGTR1 (0.45) | AGTR1AGTR2FEN1PLA2G2AKDM4E | |
| SCHEMBL7422972 | 0.90 | HTT (0.45) | AGTR1AGTR2KDM4E | |
| SCHEMBL7421489 | 0.85 | SLC22A12 (0.43) | AGTR1AGTR2KDM4EALDH1A1LMNA | |
| SCHEMBL7427533 | 0.85 | ALOX5AP (0.46) | ALDH1A1PPARG | |
| SCHEMBL7419910 | 0.85 | AGTR1 (0.46) | AGTR1AGTR2FEN1PLA2G2AKDM4E | |
| SCHEMBL7427161 | 0.85 | AGTR1 (0.38) | AGTR1AGTR2PLA2G2AKDM4EALDH1A1 | |
| SCHEMBL7425450 | 0.85 | AGTR1 (0.46) | AGTR1AGTR2ALDH1A1 | |
| SCHEMBL7424763 | 0.84 | AGTR1 (0.39) | AGTR1AGTR2KDM4EALDH1A1PPARG | |
| SCHEMBL7707842 | 0.84 | ALOX5AP (0.45) | ALDH1A1PPARG | |
| SCHEMBL7422911 | 0.83 | AGTR1 (0.48) | AGTR1AGTR2FEN1PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |