Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 4/20 | 0.53 |
| ▸ | CA2 | P00918 | 4/20 | 0.53 |
| ▸ | CA9 | Q16790 | 4/20 | 0.53 |
| ▸ | CA12 | O43570 | 3/20 | 0.53 |
| ▸ | CA7 | P43166 | 3/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22426668 | 0.83 | NR4A2 (0.46) | LMNATSHRSMN1; SMN2HSD17B10HPGD | |
| SCHEMBL25258585 | 0.82 | PTPN11 (0.55) | LMNACA1CA2CA9CA12 | |
| SCHEMBL31046806 | 0.82 | PTPN11 (0.55) | LMNACA1CA2CA9CA12 | |
| SCHEMBL8203446 | 0.82 | LMNA (0.63) | LMNATSHRCA1CA2CA9 | |
| SCHEMBL8118111 | 0.81 | NR4A2 (0.48) | LMNATSHRSMN1; SMN2HSD17B10HPGD | |
| SCHEMBL4047702 | 0.81 | ALDH1A1 (0.55) | TSHRCA1CA2CA9CA12 | |
| SCHEMBL5242666 | 0.80 | ATR (0.58) | LMNATSHRCA1CA2CA9 | |
| SCHEMBL28805897 | 0.79 | POLB (0.45) | LMNATSHRSMN1; SMN2HSD17B10HPGD | |
| SCHEMBL7413793 | 0.79 | MAPK1 (0.47) | LMNATSHRSMN1; SMN2HSD17B10HPGD | |
| SCHEMBL205172 | 0.77 | PTPN11 (0.62) | CA1CA2SMN1; SMN2PTPN11HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118420558-B | Zhu Gongjun acid derivative and preparation method and application thereof | 济南爱思医药科技有限公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-118420558-A | Zhu Gongjun acid derivative and preparation method and application thereof | 济南爱思医药科技有限公司 | 2024-08-02 | — | — | CN | disclosed |
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |