Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11213631 | 0.88 | LTA4H (0.60) | MAPK14LTA4HLMNAMAPTALDH1A1 | |
| SCHEMBL7423017 | 0.81 | LTA4H (0.60) | LTA4HLMNAMAPTALDH1A1KDM4E | |
| SCHEMBL17873926 | 0.76 | LTA4H (0.60) | LTA4HLMNAMAPTALDH1A1KDM4E | |
| SCHEMBL6727553 | 0.74 | LTA4H (0.58) | LTA4HLMNAMAPTALDH1A1KDM4E | |
| SCHEMBL6730999 | 0.74 | LTA4H (0.58) | LTA4HLMNAMAPTALDH1A1KDM4E | |
| SCHEMBL6730573 | 0.74 | LTA4H (0.72) | LTA4HMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL11215406 | 0.74 | CACNA1B (0.63) | KDM4ECACNA1BADRA2C | |
| SCHEMBL10993717 | 0.73 | LTA4H (0.60) | LTA4HMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL11216885 | 0.73 | CACNA1B (0.54) | MAPK14CACNA1BADRA2C | |
| SCHEMBL10561472 | 0.73 | ALDH1A1 (0.52) | LTA4HLMNAMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255735-A2 | PYRIDINE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001056990-A2 | PYRIDINE DERIVATES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2001-08-09 | — | — | WO | disclosed |