SCHEMBL7423017

SCHEMBL7423017

Oc1ccc(Oc2ccc(NCc3cccnc3)cc2)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 1/20 0.60
ALDH1A1 P00352 3/20 0.60
MAPT P10636 5/20 0.56
KDM4E B2RXH2 2/20 0.56
LMNA P02545 1/20 0.56
HTT P42858 1/20 0.56
NAMPT P43490 1/20 0.56
MAPK1 P28482 1/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
GAA P10253 2/20 0.52
PABPC1 P11940 1/20 0.52
TP53 P04637 1/20 0.52
BLM P54132 1/20 0.52
ATM Q13315 1/20 0.52
MMP13 P45452 1/20 0.50
SCN9A Q15858 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2C9 P11712 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6730573 0.91 LTA4H (0.72) LTA4HALDH1A1MAPTKDM4EMAPK1
SCHEMBL6833672 0.88 LTA4H (0.73) LTA4HALDH1A1MAPTKDM4ELMNA
SCHEMBL24517122 0.82 SCN9A (0.62) LTA4HALDH1A1MAPTKDM4ELMNA
SCHEMBL22776468 0.82 GAA (0.74) LTA4HALDH1A1MAPTKDM4ELMNA
SCHEMBL7423012 0.81 MAPK14 (0.48) LTA4HALDH1A1MAPTKDM4ELMNA
SCHEMBL2908596 0.81 ALDH1A1 (0.69) LTA4HALDH1A1MAPTKDM4EHTT
SCHEMBL11213631 0.80 LTA4H (0.60) LTA4HALDH1A1MAPTKDM4ELMNA
SCHEMBL6727553 0.79 LTA4H (0.58) LTA4HALDH1A1MAPTKDM4ELMNA
SCHEMBL6730999 0.79 LTA4H (0.58) LTA4HALDH1A1MAPTKDM4ELMNA
SCHEMBL23873637 0.78 ALDH1A1 (0.72) LTA4HALDH1A1MAPTKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1255735-A2 PYRIDINE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS ELI LILLY AND COMPANY (US) 2002-11-13 EP disclosed
WO-2001056990-A2 PYRIDINE DERIVATES AS POTENTIATORS OF GLUTAMATE RECEPTORS ELI LILLY AND COMPANY (US) 2001-08-09 WO disclosed