Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 14/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423416 | 0.90 | AGTR1 (0.44) | S1PR3AGTR1GMNNLMNACYP1A2 | |
| SCHEMBL7425589 | 0.89 | CTRB1 (0.42) | S1PR3AGTR1GMNNLMNACYP1A2 | |
| SCHEMBL7424404 | 0.86 | S1PR3 (0.42) | S1PR3TP53MAPTTHRB | |
| SCHEMBL7425040 | 0.86 | MAPT (0.41) | S1PR3LMNATSHRPOLBTP53 | |
| SCHEMBL7422342 | 0.84 | S1PR3 (0.42) | S1PR3LMNATSHRHIF1ANPSR1 | |
| SCHEMBL7468201 | 0.83 | MEN1 (0.43) | S1PR3AGTR1LMNATSHRNPSR1 | |
| SCHEMBL7470080 | 0.83 | S1PR3 (0.41) | S1PR3AGTR1HPGDCNR2TP53 | |
| SCHEMBL7420331 | 0.83 | S1PR3 (0.41) | S1PR3TP53MAPTTHRB | |
| SCHEMBL7416292 | 0.83 | S1PR3 (0.46) | S1PR3LMNACYP1A2CYP3A4TSHR | |
| SCHEMBL7425401 | 0.83 | MAPT (0.43) | S1PR3LMNAHPGDTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358992-B1 | Method of inhibiting neoplastic cells with indole derivatives | CELL PATHWAYS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |