Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.53 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.53 |
| ▸ | PLAU | P00749 | 4/20 | 0.53 |
| ▸ | PLG | P00747 | 3/20 | 0.53 |
| ▸ | PLAT | P00750 | 3/20 | 0.53 |
| ▸ | F2 | P00734 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983619 | 0.90 | F10 (0.57) | DRD2DRD3HRH3PRSS1KLKB1 | |
| SCHEMBL7986010 | 0.89 | PRSS1 (0.63) | DRD3HRH3NR1H4PRSS1PLAU | |
| SCHEMBL7972021 | 0.86 | F10 (0.56) | DRD2DRD3HRH3PRSS1KLKB1 | |
| SCHEMBL7392566 | 0.86 | F10 (0.56) | DRD2DRD3HRH3PRSS1KLKB1 | |
| SCHEMBL7972008 | 0.85 | F10 (0.62) | DRD2DRD3HRH3PRSS1KLKB1 | |
| SCHEMBL23751141 | 0.85 | NR1H4 (0.72) | NR1H4PRSS1KLKB1PLAUPLG | |
| SCHEMBL7982578 | 0.85 | TMPRSS2 (0.64) | DRD3HRH3PRSS1PLAUPLG | |
| SCHEMBL7419632 | 0.85 | PRSS1 (0.64) | DRD3HRH3PRSS1PLAUPLG | |
| SCHEMBL7425136 | 0.85 | PRSS1 (0.57) | PRSS1PLAUF2F10LOX | |
| SCHEMBL7989809 | 0.85 | PRSS1 (0.57) | PRSS1PLAUF2F10LOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221914-B1 | ANTIINFLAMMATORY AGENTS | ARRAY BIOPHARMA INC. | 2001-04-24 | — | — | US | disclosed |
| WO-1999024395-A1 | COMPOUNDS WHICH INHIBIT TRYPTASE ACTIVITY | ARRAY BIOPHARMA, INC. (US) | 1999-05-20 | — | — | WO | disclosed |