Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 11/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7426435 | 0.91 | KMT2A (0.40) | POLBLMNA | |
| SCHEMBL7425320 | 0.84 | KDM4E (0.38) | POLB | |
| SCHEMBL6950389 | 0.84 | POLB (0.49) | POLBTSHRCASP6HCAR3LMNA | |
| SCHEMBL8327806 | 0.78 | POLB (0.44) | POLBTSHRCASP6HCAR3LMNA | |
| SCHEMBL8327873 | 0.78 | POLB (0.44) | POLBTSHRCASP6HCAR3LMNA | |
| SCHEMBL14498139 | 0.78 | SLC6A4 (0.47) | — | |
| SCHEMBL8327876 | 0.78 | POLB (0.44) | POLBTSHRCASP6HCAR3LMNA | |
| SCHEMBL8327809 | 0.78 | POLB (0.44) | POLBTSHRCASP6HCAR3LMNA | |
| SCHEMBL7338212 | 0.78 | POLB (0.44) | POLBTSHRCASP6HCAR3LMNA | |
| SCHEMBL28691449 | 0.78 | HSD11B1 (0.47) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495545-B1 | ANTIOSTEOPOROTIC, ANTIRESTENOTIC, ANTICARCINOGENIC AND ANTIATHEROSCLEROTIC ACTIVITY | BAYER AKTIENGESELLSCHAFT (DE) | 2002-12-17 | — | — | US | disclosed |
| US-6339083-B1 | FOR THERAPY OF OSTEOPOROSIS, RESTENOSIS, CARCINOSES AND/OR ARTERIOSCLEROSIS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-01-15 | — | — | US | disclosed |
| EP-1140927-A1 | 1,4-BENZODIAZEPINONE DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | Bayer Aktiengesellschaft (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035917-A1 | 1,4-BENZODIAZEPINONE DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | BAYER AKTIENGESELLSCHAFT (DE) | 2000-06-22 | — | — | WO | disclosed |