Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423995 | 0.91 | POLB (0.44) | LMNAPOLB | |
| SCHEMBL7429986 | 0.84 | ALOX15 (0.42) | RENHPGDGPR119ALDH1A1 | |
| SCHEMBL6948552 | 0.84 | KMT2A (0.44) | KMT2AMEN1HPGDATMALDH1A1 | |
| SCHEMBL6655650 | 0.83 | KMT2A (0.43) | KMT2AMEN1HPGDATMALDH1A1 | |
| SCHEMBL8329755 | 0.78 | KMT2A (0.40) | KMT2AMEN1ATMLMNAGAA | |
| SCHEMBL8326945 | 0.78 | KMT2A (0.40) | KMT2AMEN1HPGDATMALDH1A1 | |
| SCHEMBL14498139 | 0.78 | SLC6A4 (0.47) | KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL7427324 | 0.78 | ALDH1A1 (0.46) | KMT2AMEN1HPGDALDH1A1LMNA | |
| SCHEMBL6378448 | 0.78 | KMT2A (0.44) | KMT2AMEN1HPGDATMALDH1A1 | |
| SCHEMBL6948474 | 0.77 | MAPT (0.43) | KMT2AMEN1HPGDATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495545-B1 | ANTIOSTEOPOROTIC, ANTIRESTENOTIC, ANTICARCINOGENIC AND ANTIATHEROSCLEROTIC ACTIVITY | BAYER AKTIENGESELLSCHAFT (DE) | 2002-12-17 | — | — | US | disclosed |
| US-6339083-B1 | FOR THERAPY OF OSTEOPOROSIS, RESTENOSIS, CARCINOSES AND/OR ARTERIOSCLEROSIS | BAYER AKTIENGESELLSCHAFT (DE) | 2002-01-15 | — | — | US | disclosed |
| EP-1140927-A1 | 1,4-BENZODIAZEPINONE DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | Bayer Aktiengesellschaft (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035917-A1 | 1,4-BENZODIAZEPINONE DERIVATIVES AND THEIR USE AS INTEGRIN ANTAGONISTS | BAYER AKTIENGESELLSCHAFT (DE) | 2000-06-22 | — | — | WO | disclosed |