Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 10/20 | 0.45 |
| ▸ | NOS3 | P29474 | 7/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7594405 | 0.88 | NOS2 (0.44) | NOS2NOS3 | |
| Hydrochloric Acid SCHEMBL7398282 | 0.86 | NOS3 (0.43) | NOS2NOS3 | |
| SCHEMBL7592051 | 0.85 | NOS2 (0.46) | NOS2NOS3SLC6A4SLC6A3 | |
| SCHEMBL7398641 | 0.79 | KDM4E (0.38) | NOS2NOS3 | |
| SCHEMBL7423582 | 0.77 | NOS2 (0.41) | NOS2NOS3 | |
| SCHEMBL7418032 | 0.77 | NOS2 (0.41) | NOS2NOS3 | |
| SCHEMBL7417662 | 0.77 | NOS2 (0.41) | NOS2NOS3 | |
| SCHEMBL7420397 | 0.76 | NOS2 (0.49) | NOS2NOS3 | |
| Hydrochloric Acid SCHEMBL7383900 | 0.76 | NOS3 (0.40) | NOS2NOS3 | |
| SCHEMBL7432079 | 0.74 | NOS3 (0.38) | NOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000073313-A1 | NEW TRICYCLIC AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2000-12-07 | — | — | WO | claimed |
| WO-2000073313-A1 | NEW TRICYCLIC AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2000-12-07 | — | — | WO | disclosed |