Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 4/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.55 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.55 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | TMPRSS15 | P98073 | 8/20 | 0.49 |
| ▸ | ACR | P10323 | 2/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.43 |
| ▸ | KLK1 | P06870 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7432469 | 0.92 | PRSS1 (0.53) | PRSS1F2PRSS2PRSS3PARP10 | |
| SCHEMBL27650063 | 0.91 | PRSS1 (0.63) | PRSS1F2PRSS2PRSS3PARP10 | |
| Hydrochloric Acid SCHEMBL7426558 | 0.89 | PRSS1 (0.61) | PRSS1F2PRSS2PRSS3PARP10 | |
| Trifluoroacetic Acid SCHEMBL22657794 | 0.89 | PRSS1 (0.56) | PRSS1F2PRSS2PRSS3PARP10 | |
| SCHEMBL16180747 | 0.84 | PARP10 (0.64) | PRSS1F2PRSS2PRSS3PARP10 | |
| Trifluoroacetic Acid SCHEMBL7432454 | 0.84 | TMPRSS15 (0.46) | PRSS1F2PRSS2PRSS3TMPRSS15 | |
| Hydrochloric Acid SCHEMBL7427372 | 0.84 | PRSS1 (0.59) | PRSS1F2PRSS2PRSS3PARP10 | |
| Hydrochloric Acid SCHEMBL7424233 | 0.81 | PRSS1 (0.59) | PRSS1F2PRSS2PRSS3PARP10 | |
| Trifluoroacetic Acid SCHEMBL28281967 | 0.80 | LOXL2 (0.77) | LOXL2MAPTTSHRTDP1MEN1 | |
| SCHEMBL7429172 | 0.80 | PRSS1 (0.66) | PRSS1F2PRSS2PRSS3PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073624-A1 | AMINOMETHYL-BENZOIC ESTER DERIVATIVES AS TRYPTASE INHIBITORS | Proteus Molecular Design Limited (GB) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999055661-A1 | AMINOMETHYL-BENZOIC ESTER DERIVATIVES AS TRYPTASE INHIBITORS | PROTEUS MOLECULAR DESIGN LIMITED (GB) | 1999-11-04 | — | — | WO | disclosed |