SCHEMBL7424319

SCHEMBL7424319

N=C(NCCCNc1ncccc1Cc1ccc(Br)cc1)NCCc1c[nH]cn1

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SSTR4 P31391 1/20 0.32
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8189126 0.96 SSTR4 (0.32) SSTR4MEN1KMT2A
SCHEMBL7419465 0.76 SSTR4 (0.45) SSTR4MEN1KMT2A
SCHEMBL7429330 0.73 SSTR4 (0.56) SSTR4MEN1KMT2A
SCHEMBL7425273 0.72 SSTR4 (0.47) SSTR4MEN1KMT2A
SCHEMBL8617900 0.69 RAB9A (0.43)
SCHEMBL7476252 0.69 SSTR4 (0.61) SSTR4MEN1KMT2A
SCHEMBL7421173 0.69
SCHEMBL9827825 0.68 CHRM2 (0.45)
SCHEMBL9867117 0.67 L3MBTL1 (0.43) KMT2A
SCHEMBL7421170 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1019050-B1 USE OF SOMATOSTATIN AGONISTS AND ANTAGONISTS FOR TREATING DISEASES RELATED TO THE EYE NOVO NORDISK AS (DK) 2002-03-20 EP claimed
US-6159941-A Use of somatostatin agonists and antagonists for treating diseases related to the eye NOVO NORDISK A/S (DK) 2000-12-12 US claimed
US-6127343-A SELECTIVE, COMPETITIVE SOMATOSTATIN RECEPTOR LIGANDS OF NONPEPTIDE ORIGIN, FOR MEDIATING THE BIOLOGICAL EFFECT OF SOMATOSTATIN AGONISTS OR ANTAGONIST NOVO NORDISK A/S (DK) 2000-10-03 US claimed
EP-1019050-A1 USE OF SOMATOSTATIN AGONISTS AND ANTAGONISTS FOR TREATING DISEASES RELATED TO THE EYE NOVO NORDISK A/S (DK) 2000-07-19 EP claimed
EP-0912551-A1 SOMATOSTATIN AGONISTS AND ANTAGONISTS NOVO NORDISK A/S (DK) 1999-05-06 EP claimed
WO-1998058646-A1 USE OF SOMATOSTATIN AGONISTS AND ANTAGONISTS FOR TREATING DISEASES RELATED TO THE EYE NOVO NORDISK A/S (DK) 1998-12-30 WO claimed
WO-1997043278-A1 SOMATOSTATIN AGONISTS AND ANTAGONISTS NOVO NORDISK A/S (DK) 1997-11-20 WO claimed