Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7419833 | 0.86 | NOTUM (0.54) | NOTUMMAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL7418643 | 0.80 | NOTUM (0.56) | NOTUMMAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL5781313 | 0.78 | NOTUM (0.57) | NOTUMMAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL1948510 | 0.73 | NOTUM (0.64) | NOTUMMAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL13002857 | 0.71 | NOTUM (0.65) | NOTUMMAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL14148139 | 0.71 | NOTUM (0.60) | NOTUMMAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL4240300 | 0.71 | TRIM24 (0.60) | NOTUMMAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL11682254 | 0.70 | SMN1; SMN2 (0.70) | NOTUMMAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL3767593 | 0.69 | SMN1; SMN2 (0.72) | NOTUMMAPTSMN1; SMN2NPC1TP53 | |
| SCHEMBL7413801 | 0.69 | LMNA (0.57) | NOTUMMAPTSMN1; SMN2NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994004533-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-03-03 | — | — | WO | disclosed |