Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8805666 | 0.85 | KDM4E (0.52) | LMNAMAPTALDH1A1TP53RAB9A | |
| SCHEMBL6841370 | 0.85 | CREBBP (0.50) | LMNAMAPTALDH1A1TP53RAB9A | |
| SCHEMBL9389498 | 0.85 | KCNH2 (0.52) | LMNAMAPTALDH1A1TP53RAB9A | |
| SCHEMBL24011079 | 0.78 | NOTUM (0.84) | LMNAMAPTALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL11682254 | 0.77 | SMN1; SMN2 (0.70) | LMNAMAPTALDH1A1TP53RAB9A | |
| SCHEMBL24011118 | 0.77 | LMNA (0.71) | LMNAMAPTALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL6984459 | 0.76 | FPR1 (0.44) | LMNAALDH1A1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL3767593 | 0.76 | SMN1; SMN2 (0.72) | LMNAMAPTALDH1A1TP53RAB9A | |
| SCHEMBL24011069 | 0.76 | NOTUM (0.82) | LMNAALDH1A1TP53NOTUMPDK1 | |
| SCHEMBL3102790 | 0.76 | NOTUM (0.62) | LMNAMAPTALDH1A1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656003-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-06-07 | — | — | EP | disclosed |
| WO-1994004533-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT2C AND 5HT2B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-03-03 | — | — | WO | disclosed |