Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 5/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7426031 | 0.94 | TDP2 (0.44) | TDP2MAOBMETGRM5SPHK2 | |
| SCHEMBL7424354 | 0.85 | SLC6A4 (0.42) | TDP2MAOBMETGRM5SLC6A4 | |
| SCHEMBL7433220 | 0.80 | MET (0.49) | METSPHK2SPHK1SLC6A4ALOX5AP | |
| SCHEMBL7424903 | 0.78 | ALOX5AP (0.49) | METSPHK2SPHK1SLC6A4ALOX5AP | |
| SCHEMBL7429461 | 0.76 | MET (0.50) | METSPHK2SPHK1SLC6A4ALOX5AP | |
| SCHEMBL7424878 | 0.74 | PDE3B (0.52) | MAOBMETSPHK2SPHK1SLC6A4 | |
| SCHEMBL7429033 | 0.74 | ALOX5AP (0.48) | METSPHK2SPHK1SLC6A4ALOX5AP | |
| SCHEMBL7428366 | 0.73 | HDAC1 (0.44) | METALOX5AP | |
| SCHEMBL7421616 | 0.73 | MAOB (0.52) | MAOBMETSPHK2SPHK1SLC6A4 | |
| SCHEMBL7420583 | 0.72 | SCN7A (0.40) | METALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107954-A1 | 2-OXO-$i(2H)-QUINOLINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012479-A1 | 2-OXO-2H-QUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-03-09 | — | — | WO | disclosed |