Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.41 |
| ▸ | CFD | P00746 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7421616 | 0.93 | MAOB (0.52) | PDE3BPDE3ASLC6A4DAOL3MBTL1 | |
| SCHEMBL7424881 | 0.82 | SLC6A4 (0.52) | SLC6A4DAOL3MBTL1SPHK2SPHK1 | |
| SCHEMBL7433220 | 0.78 | MET (0.49) | SLC6A4DAOL3MBTL1SPHK2SPHK1 | |
| SCHEMBL7429461 | 0.77 | MET (0.50) | SLC6A4DAOL3MBTL1SPHK2SPHK1 | |
| SCHEMBL7295341 | 0.76 | SPHK2 (0.59) | SLC6A4L3MBTL1MAOBSPHK2SPHK1 | |
| SCHEMBL7424903 | 0.76 | ALOX5AP (0.49) | SLC6A4DAOL3MBTL1SPHK2SPHK1 | |
| SCHEMBL3373971 | 0.75 | MAOB (0.65) | PDE3BPDE3AL3MBTL1MAOBACHE | |
| SCHEMBL7429033 | 0.74 | ALOX5AP (0.48) | SLC6A4DAOL3MBTL1SPHK2SPHK1 | |
| SCHEMBL7424352 | 0.74 | TDP2 (0.44) | SLC6A4DAOMAOBSPHK2SPHK1 | |
| SCHEMBL7426031 | 0.72 | TDP2 (0.44) | SLC6A4DAOL3MBTL1MAOBSPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107954-A1 | 2-OXO-$i(2H)-QUINOLINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012479-A1 | 2-OXO-2H-QUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2000-03-09 | — | — | WO | disclosed |