Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.48 |
| ▸ | PDE4A | P27815 | 6/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7858782 | 0.90 | CASP1 (0.49) | CASP1HSD17B10PDE4BPDE4APDE4C | |
| SCHEMBL7866895 | 0.86 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7384417 | 0.86 | HSD17B10 (0.66) | CASP1HSD17B10L3MBTL1 | |
| SCHEMBL5703639 | 0.83 | PDE4B (0.50) | CASP1HSD17B10PDE4BPDE4APDE4C | |
| SCHEMBL11099776 | 0.80 | HSD17B10 (0.51) | CASP1HSD17B10L3MBTL1 | |
| SCHEMBL7865357 | 0.80 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7421932 | 0.79 | CASP1 (0.53) | CASP1HSD17B10PDE4BPDE4APDE4C | |
| SCHEMBL11830247 | 0.77 | CASP1 (0.54) | CASP1HSD17B10L3MBTL1 | |
| SCHEMBL6584961 | 0.76 | PDE4B (0.44) | CASP1HSD17B10PDE4BPDE4APDE4C | |
| SCHEMBL5498121 | 0.76 | PDE4B (0.45) | CASP1HSD17B10PDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636025-B1 | COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORP (US) | 2001-07-18 | — | — | EP | disclosed |
| EP-0633775-B1 | COMPOUNDS USEFUL FOR TREATING INFLAMMATORY DISEASES AND FOR INHIBITING PRODUCTION OF TUMOR NECROSIS FACTOR | SMITHKLINE BEECHAM CORP (US) | 2000-05-31 | — | — | EP | disclosed |
| US-5811455-A | Compounds useful for treating allergic or inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1998-09-22 | — | — | US | disclosed |
| US-5631286-A | Compounds useful for treating allergic or inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-20 | — | — | US | disclosed |
| EP-0636025-A4 | COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES. | — | 1995-02-22 | — | — | EP | disclosed |
| EP-0636025-A1 | COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993019750-A1 | COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-10-14 | — | — | WO | disclosed |