Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.48 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 4/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | BRS3 | P32247 | 2/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.38 |
| ▸ | KDM6B | O15054 | 3/20 | 0.38 |
| ▸ | KDM4A | O75164 | 3/20 | 0.38 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.38 |
| ▸ | KDM3B | Q7LBC6 | 3/20 | 0.38 |
| ▸ | HIF1AN | Q9NWT6 | 3/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27374286 | 0.89 | BRS3 (0.47) | MMP2PIN1MMP13MMP9BRS3 | |
| SCHEMBL4506135 | 0.85 | PIN1 (0.46) | MMP2PIN1MMP13MMP9HCAR2 | |
| SCHEMBL27394755 | 0.84 | MMP2 (0.43) | MMP2MMP13MMP9BRS3GLA | |
| SCHEMBL4908556 | 0.81 | MMP2 (0.44) | MMP2PIN1MMP13MMP9BRS3 | |
| SCHEMBL8653203 | 0.81 | MMP2 (0.67) | MMP2MMP13MMP9BRS3GLA | |
| SCHEMBL14012152 | 0.78 | PIN1 (0.43) | MMP2PIN1MMP13MMP9HCAR2 | |
| SCHEMBL9938772 | 0.77 | MMP2 (0.71) | MMP2PIN1MMP13MMP9BRS3 | |
| SCHEMBL1422384 | 0.77 | MMP2 (0.48) | MMP2PIN1MMP13MMP9BRS3 | |
| SCHEMBL20630518 | 0.77 | PIN1 (0.46) | MMP2PIN1MMP13MMP9HCAR2 | |
| SCHEMBL12821931 | 0.76 | MMP13 (0.44) | MMP2PIN1MMP13MMP9HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102351849-B | Preparation method of olmesartan medoxomil | QILU TIANHE PHARMACEUTICAL CO LTD | 2013-10-02 | — | — | CN | claimed |
| CN-102070533-A | New method for synthesizing 4-(1-hydroxyl-1-methyl ethyl)-2-propyl imidazole-5-carboxylic acid ethyl ester | SHANGHAI SYNCORES TECHNOLOGIES INC | 2011-05-25 | — | — | CN | claimed |
| CN-109081812-A | 4- (1- hydroxyl -1- Methylethyl) -2- propyl imidazole -5- carboxylic acid, ethyl ester monohydrate | 黄冈鲁班药业股份有限公司 | 2018-12-25 | — | — | CN | disclosed |
| CN-106749195-A | A kind of olmesartan medoxomil intermediate impurities synthesis, the method for identification | 青岛黄海制药有限责任公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-104356069-B | The preparation method and application of olmesartan medoxomil intermediate 4-(1-hydroxyl-1-Methylethyl)-2-propyl imidazole-5-carboxylic acid, ethyl ester | 黄冈鲁班药业有限公司 | 2016-09-14 | — | — | CN | disclosed |
| CN-102070533-A | New method for synthesizing 4-(1-hydroxyl-1-methyl ethyl)-2-propyl imidazole-5-carboxylic acid ethyl ester | SHANGHAI SYNCORES TECHNOLOGIES INC | 2011-05-25 | — | — | CN | disclosed |
| CN-1056140-C | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 2000-09-06 | — | — | CN | disclosed |
| EP-0986562-A1 | SUBSTITUTED 1,2,4-TRIAZOLO 3,4-A]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998050385-A1 | SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1998-11-12 | — | — | WO | disclosed |
| WO-1997016192-A1 | MUSCARINE ANTAGONISTS | MERCK & CO., INC. (US) | 1997-05-09 | — | — | WO | disclosed |
| EP-0748315-A1 | USE OF IMIDAZOLE DERIVATIVES FOR TREATING DISORDERS INVOLVING ANGIOTENSIN RECEPTORS AT 1? AND AT 2?, CERTAIN SUCH PRODUCTS, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ROUSSEL UCLAF (FR) | 1996-12-18 | — | — | EP | disclosed |
| CN-1095374-A | Biphenyl derivatives, their preparation and they are in the application for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 1994-11-23 | — | — | CN | disclosed |
| CN-1065063-A | 1-Biphenylmethylimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1992-10-07 | — | — | CN | disclosed |