Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.64 |
| ▸ | BACE1 | P56817 | 7/20 | 0.64 |
| ▸ | BCHE | P06276 | 5/20 | 0.64 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CCR3 | P51677 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8805002 | 1.00 | ACHE (0.64) | ACHEBACE1BCHECXCR3GAA | |
| SCHEMBL8408423 | 0.98 | ACHE (0.66) | ACHEBACE1BCHECXCR3GAA | |
| SCHEMBL25104895 | 0.92 | BCHE (0.64) | ACHEBACE1BCHECXCR3GAA | |
| SCHEMBL2840739 | 0.91 | ACHE (0.70) | ACHEBACE1BCHECXCR3GAA | |
| SCHEMBL3316924 | 0.85 | MC4R (0.64) | ACHEBACE1BCHECXCR3GAA | |
| SCHEMBL1815714 | 0.84 | SIGMAR1 (0.62) | ACHESIGMAR1KDM4ECCR3DRD2 | |
| SCHEMBL3122690 | 0.84 | ACHE (0.60) | ACHEBACE1BCHECXCR3GAA | |
| SCHEMBL34474661 | 0.83 | BCHE (0.69) | ACHEBACE1BCHECXCR3SIGMAR1 | |
| SCHEMBL11102768 | 0.82 | ACHE (0.55) | ACHEBACE1BCHECXCR3GAA | |
| SCHEMBL8186709 | 0.81 | ACHE (0.66) | ACHEBACE1BCHECXCR3DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012147-A2 | O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-28 | — | — | EP | disclosed |
| WO-1999006387-A2 | O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-02-11 | — | — | WO | disclosed |