Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.66 |
| ▸ | BACE1 | P56817 | 9/20 | 0.66 |
| ▸ | BCHE | P06276 | 6/20 | 0.66 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.58 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | KDM1A | O60341 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | CCR3 | P51677 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3311538 | 0.98 | ACHE (0.68) | ACHEBACE1BCHECXCR4CXCR3 | |
| SCHEMBL28169202 | 0.89 | CXCR4 (0.68) | ACHEBACE1BCHECXCR4MEN1 | |
| SCHEMBL8228694 | 0.84 | BCHE (0.57) | ACHEBACE1BCHECXCR4MEN1 | |
| SCHEMBL8576045 | 0.84 | BCHE (0.73) | ACHEBACE1BCHECXCR4 | |
| SCHEMBL20183336 | 0.84 | BCHE (0.73) | ACHEBACE1BCHECXCR4 | |
| SCHEMBL31014995 | 0.82 | BCHE (0.58) | ACHEBACE1BCHEKDM1AMAOB | |
| SCHEMBL7424698 | 0.81 | ACHE (0.64) | ACHEBACE1BCHECXCR3MEN1 | |
| SCHEMBL8805002 | 0.81 | ACHE (0.64) | ACHEBACE1BCHECXCR3MEN1 | |
| SCHEMBL9437321 | 0.81 | ACHE (0.60) | ACHEBACE1BCHECXCR4MEN1 | |
| SCHEMBL31014655 | 0.80 | BCHE (0.61) | ACHEBACE1BCHEMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156752-A | Optically active 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC (US) | 2000-12-05 | — | — | US | disclosed |
| EP-0899261-A1 | Optical active 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC. (US) | 1999-03-03 | — | — | EP | disclosed |