Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CTSD | P07339 | 1/20 | 0.53 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3325012 | 0.82 | ALDH1A1 (0.63) | ALDH1A1CTSDCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL23037578 | 0.80 | TSHR (0.62) | ALDH1A1CTSDCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1428895 | 0.79 | ALDH1A1 (0.60) | ALDH1A1CTSDGPR35CYP1A2CYP3A4 | |
| SCHEMBL4078013 | 0.79 | ALDH1A1 (0.64) | ALDH1A1CTSDGPR35CYP1A2CYP3A4 | |
| SCHEMBL20987678 | 0.78 | ALDH1A1 (0.63) | ALDH1A1CTSDGPR35CYP1A2CYP3A4 | |
| SCHEMBL975117 | 0.77 | ALDH1A1 (0.68) | ALDH1A1CTSDGPR35CYP1A2CYP3A4 | |
| SCHEMBL10613860 | 0.77 | ALDH1A1 (0.68) | ALDH1A1CTSDGPR35CYP1A2CYP3A4 | |
| SCHEMBL8592467 | 0.75 | ALDH1A1 (0.60) | ALDH1A1CTSDGPR35CYP1A2CYP3A4 | |
| SCHEMBL29696138 | 0.75 | TSHR (0.67) | ALDH1A1CTSDCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL436389 | 0.75 | ALDH1A1 (0.66) | ALDH1A1CTSDGPR35CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691311-A | Methods for coating invasive devices with inhibitors of thrombin | BIOGEN, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| EP-0489070-B1 | NOVEL INHIBITORS OF THROMBIN | BIOGEN INC (US) | 1996-04-24 | — | — | EP | disclosed |
| US-5433940-A | Synthetic molecules mimic action of hirudin by binding to both the low affinity anion-binding exosite and the catalytic site of thrombin | BIOGEN, INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5196404-A | Hirudin mimic, polypeptide, hirulog; bivalirudin FDA Orange book listed patent | BIOGEN, INC. (US) | 1993-03-23 | — | — | US | disclosed |
| EP-0489070-A1 | NOVEL INHIBITORS OF THROMBIN. | BIOGEN INC (US) | 1992-06-10 | — | — | EP | disclosed |
| EP-0482069-A1 | COMBINATIONS AND METHODS FOR TREATING OR PREVENTING THROMBOTIC DISEASES | BIOGEN, INC. (US) | 1992-04-29 | — | — | EP | disclosed |
| WO-1991002750-A1 | NOVEL INHIBITORS OF THROMBIN | BIOGEN, INC. (US) | 1991-03-07 | — | — | WO | disclosed |
| WO-1991001142-A1 | COMBINATIONS AND METHODS FOR TREATING OR PREVENTING THROMBOTIC DISEASES | BIOGEN, INC. (US) | 1991-02-07 | — | — | WO | disclosed |
| WO-1990003391-A1 | HIRUDIN PEPTIDES | BIOGEN, INC. (US) | 1990-04-05 | — | — | WO | disclosed |
| EP-0333356-A2 | Hirudin peptides | BIOGEN, INC. (US) | 1989-09-20 | — | — | EP | disclosed |