SCHEMBL7425014

SCHEMBL7425014

COc1cc(N(CCC2CCN(C(CC(=O)O)c3ccccc3)CC2)C(C)=O)ccc1NC(=O)Nc1ccccc1C

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ACHE P22303 6/20 0.46
ITGB1 P05556 8/20 0.45
ITGA4 P13612 8/20 0.45
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
CCR3 P51677 2/20 0.39
GAA P10253 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7535877 0.95 ITGA4 (0.43) ACHEITGB1ITGA4MEN1KMT2A
SCHEMBL7425392 0.94 ITGB1 (0.44) ACHEITGB1ITGA4MEN1KMT2A
SCHEMBL7432383 0.93 ITGB1 (0.45) ACHEITGB1ITGA4MEN1KMT2A
SCHEMBL7428874 0.91 ACHE (0.47) ACHEITGB1ITGA4MEN1KMT2A
SCHEMBL7424839 0.90 ITGA4 (0.43) ACHEITGB1ITGA4MEN1KMT2A
SCHEMBL7426361 0.87 ITGB1 (0.46) ITGB1ITGA4MEN1KMT2ACCR3
SCHEMBL7393503 0.86 ACHE (0.49) ACHEITGB1ITGA4MEN1KMT2A
SCHEMBL7431414 0.86 ACHE (0.54) ACHEITGB1ITGA4MEN1KMT2A
SCHEMBL7428920 0.85 ITGB1 (0.47) ITGB1ITGA4MEN1KMT2ACCR3
SCHEMBL7425433 0.84 ACHE (0.52) ACHEITGB1ITGA4MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999054321-A1 SUBSTITUTED DIAMINES AND THEIR USE AS CELL ADHESION INHIBITORS AVENTIS PHARMA LIMITED (GB) 1999-10-28 WO disclosed