Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | FASN | P49327 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5063459 | 0.86 | MAPT (0.49) | PDE4BMAPTALDH1A1KMT2AKDM4E | |
| SCHEMBL770303 | 0.83 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DHSD11B1 | |
| SCHEMBL15378283 | 0.83 | KCNH2 (0.34) | HSD11B1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL772492 | 0.83 | L3MBTL3 (0.33) | HSD11B1MAPTALDH1A1RBP4L3MBTL1 | |
| SCHEMBL2824310 | 0.81 | RAB9A (0.35) | HSD11B1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL2938032 | 0.81 | RAB9A (0.35) | HSD11B1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL771594 | 0.80 | NPC1 (0.32) | HSD11B1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL770413 | 0.80 | RBP4 (0.38) | HSD11B1MAPTALDH1A1RBP4L3MBTL1 | |
| SCHEMBL770338 | 0.79 | GLA (0.42) | PDE4BALDH1A1KMT2ANAMPT | |
| SCHEMBL771656 | 0.79 | MAPK1 (0.36) | PDE4BMAPTALDH1A1KMT2ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975600-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS ANTITHROMBOTIC AGENTS | Akzo Nobel N.V. (NL) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998047876-A1 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS ANTITHROMBOTIC AGENTS | AKZO NOBEL N.V. (NL) | 1998-10-29 | — | — | WO | disclosed |