Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23002177 | 0.86 | ITGB3 (0.35) | SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL442313 | 0.85 | CYP3A4 (0.35) | SMN1; SMN2 | |
| SCHEMBL4186198 | 0.77 | AGTR2 (0.49) | — | |
| SCHEMBL7033589 | 0.77 | ITGB3 (0.37) | DRD1 | |
| Hydrochloric Acid SCHEMBL2236019 | 0.75 | ITGB3 (0.36) | DRD2DRD1 | |
| Methyl Alcohol SCHEMBL28518805 | 0.74 | TACR1 (0.57) | — | |
| SCHEMBL2447521 | 0.73 | ITGB3 (0.46) | — | |
| SCHEMBL10799648 | 0.73 | CHRM5 (0.42) | SMN1; SMN2KDM2B | |
| SCHEMBL27560073 | 0.70 | TACR1 (0.48) | — | |
| SCHEMBL28780552 | 0.69 | ITGB3 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1230225-A2 | PHARMACEUTICALLY ACTIVE 4-SUBSTITUTED PYRIMIDINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001032632-A2 | PHARMACEUTICALLY ACTIVE 4-SUBSTITUTED PYRIMIDINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-05-10 | — | — | WO | disclosed |