Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | F2R | P25116 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583721 | 0.81 | ALDH1A1 (0.40) | CHRM5SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10945868 | 0.80 | ALDH1A1 (0.40) | CHRM5SMN1; SMN2 | |
| SCHEMBL23002177 | 0.76 | ITGB3 (0.35) | CHRM5ITGB3ITGA2BF2RSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL442313 | 0.74 | CYP3A4 (0.35) | CHRM5ITGB3ITGA2BF2RSMN1; SMN2 | |
| SCHEMBL7425201 | 0.73 | SMN1; SMN2 (0.39) | SMN1; SMN2KDM2B | |
| SCHEMBL29896656 | 0.72 | MAPT (0.42) | CHRM5SMN1; SMN2KDM4EKDM2B | |
| SCHEMBL27584327 | 0.71 | CHRM5 (0.52) | CHRM5ADRA2CSMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL16102614 | 0.71 | CHRM5 (0.61) | CHRM5ADRA2CSMN1; SMN2ACHESIGMAR1 | |
| SCHEMBL6583551 | 0.71 | CHRM5 (0.61) | CHRM5ADRA2CSMN1; SMN2ACHESIGMAR1 | |
| SCHEMBL3009112 | 0.71 | CHRM5 (0.61) | CHRM5ADRA2CSMN1; SMN2ACHESIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0099303-B1 | BENZOTHIOPYRANOPYRIDINONES AND THEIR SALTS, THEIR PREPARATION AND USE AS MEDICAMENTS, AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1987-08-19 | — | — | EP | disclosed |
| EP-0099303-A2 | Benzothiopyranopyridinones and their salts, their preparation and use as medicaments, and compositions containing them | ROUSSEL-UCLAF (FR) | 1984-01-25 | — | — | EP | disclosed |