Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 10/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | GRN | P28799 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869312 | 0.87 | ALDH1A1 (0.42) | HPGDMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6930381 | 0.87 | ALDH1A1 (0.42) | HPGDMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7419197 | 0.84 | NPC1 (0.54) | HPGDMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL7421359 | 0.83 | THRB (0.44) | SMN1; SMN2NPC1RAB9AALDH1A1GRN | |
| SCHEMBL7383800 | 0.78 | PPARG (0.39) | MAPTMEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL8248427 | 0.77 | HPGD (0.50) | HPGDMAPTSMN1; SMN2NPY1RNPY2R | |
| SCHEMBL5869392 | 0.77 | HPGD (0.50) | HPGDMAPTSMN1; SMN2NPY1RNPY2R | |
| SCHEMBL7424962 | 0.72 | GRN (0.47) | ALDH1A1GRNSORT1LMNAMAPK1 | |
| SCHEMBL7377704 | 0.72 | GRN (0.43) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1CYP3A4 | |
| SCHEMBL7378949 | 0.71 | MME (0.50) | CYP2C19ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |