Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 4/20 | 0.47 |
| ▸ | SORT1 | Q99523 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7422452 | 0.82 | GRN (0.44) | GRNSORT1MAPK1ALDH1A1LMNA | |
| SCHEMBL7422599 | 0.81 | GRN (0.47) | GRNSORT1MAPK1ALDH1A1LMNA | |
| SCHEMBL7419482 | 0.81 | GRN (0.49) | GRNSORT1MAPK1APPALDH1A1 | |
| SCHEMBL7427316 | 0.78 | SORT1 (0.46) | GRNSORT1MAPK1ALDH1A1LMNA | |
| SCHEMBL7378949 | 0.76 | MME (0.50) | ALDH1A1LMNALTA4HMME | |
| SCHEMBL5870126 | 0.75 | GRN (0.50) | GRNSORT1MAPK1APPALDH1A1 | |
| SCHEMBL5869922 | 0.75 | GRN (0.50) | GRNSORT1MAPK1APPALDH1A1 | |
| SCHEMBL7423313 | 0.75 | CNR2 (0.42) | GRNSORT1MME | |
| SCHEMBL7421370 | 0.75 | MME (0.41) | LTA4HMME | |
| SCHEMBL7427491 | 0.75 | ENPP2 (0.45) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |