Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 6/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAT2A | P31153 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6778095 | 0.75 | NOTUM (0.56) | NOTUMNLRP3MAPK1KDM4EALDH1A1 | |
| SCHEMBL3974447 | 0.73 | HRH3 (0.53) | NOTUMNLRP3HRH3MAPK1KDM4E | |
| SCHEMBL1536322 | 0.72 | NOTUM (0.51) | NOTUMNLRP3HRH3MAPK1KDM4E | |
| SCHEMBL11337325 | 0.71 | NOTUM (0.63) | NOTUMMAPK1KDM4EALDH1A1DRD2 | |
| SCHEMBL12450338 | 0.71 | NOTUM (0.53) | NOTUMNLRP3MAPK1KDM4EALDH1A1 | |
| SCHEMBL23667579 | 0.70 | KDM4E (0.57) | NOTUMNLRP3HRH3MAPK1KDM4E | |
| SCHEMBL3760506 | 0.70 | TERT (0.50) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL28740983 | 0.70 | NOTUM (0.49) | NOTUMNLRP3HRH3MAPK1KDM4E | |
| SCHEMBL12575851 | 0.70 | NLRP3 (0.43) | NOTUMNLRP3HRH3RORCLMNA | |
| SCHEMBL28046310 | 0.69 | NCOA3 (0.56) | NOTUMNLRP3HRH3MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691967-B1 | NITROGEN-CONTAINING FUSED-HETEROCYCLE COMPOUNDS | EISAI CO LTD (JP) | 1998-09-02 | — | — | EP | disclosed |
| US-5707998-A | CYCLIC-GMP PHOSPHODIESTERASE INHIBITORS, TREATING CARDIOVASCULAR DISORDERS AND ASTHMA | EISAI CO., LTD. (JP) | 1998-01-13 | — | — | US | disclosed |
| EP-0691967-A1 | NITROGEN-CONTAINING FUSED-HETEROCYCLE COMPOUNDS | Eisai Co., Ltd. (JP) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022855-A1 | NITROGEN-CONTAINING FUSED-HETEROCYCLE COMPOUNDS | EISAI CO., LTD. (JP) | 1994-10-13 | — | — | WO | disclosed |