Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 4/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427960 | 0.95 | POLB (0.43) | KMT2AMMP1CA2CA9POLB | |
| SCHEMBL7429464 | 0.93 | POLB (0.46) | KMT2AMMP1CA2CA9POLB | |
| SCHEMBL1914901 | 0.83 | LDHA (0.56) | KMT2AMMP1CA2CA9POLB | |
| SCHEMBL1914904 | 0.83 | LDHA (0.56) | KMT2AMMP1CA2CA9POLB | |
| SCHEMBL1915705 | 0.81 | CA2 (0.52) | KMT2ACA2CA9KLK5 | |
| SCHEMBL1915701 | 0.81 | CA2 (0.52) | KMT2ACA2CA9KLK5 | |
| SCHEMBL2876345 | 0.80 | CA2 (0.51) | KMT2ACA2CA9MMEABCB1 | |
| SCHEMBL3660504 | 0.79 | KMT2A (0.44) | KMT2ACA2CA9PPARG | |
| SCHEMBL16859283 | 0.79 | CTSS (0.46) | KMT2AMMP1CA2CA9PPARG | |
| SCHEMBL1915678 | 0.79 | MME (0.42) | KMT2AMMP1CA2CA9MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133484-A2 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | AstraZeneca AB (SE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000005223-A2 | HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS | ASTRAZENECA AB (SE) | 2000-02-03 | — | — | WO | disclosed |